- Pause + Energy is a new product created by women in Menopause, exclusively for women who want to experience a second Spring
It was developed to counteract all the discomforts of Menopause such as hot flashes, mood swings, fluid retention, bloating, vaginal dryness, blood pressure fluctuations, cardiovascular risk, low motivation, weight gain, and bone pain.
Unlike synthetic products (created in laboratories) found on the market, this is the first additive-free supplement, composed solely of natural and organic plants, cultivated in Maremma, Tuscany, and throughout Italy, standardized and with effective active ingredients. It contains Red Clover, Hops, Kudzu, Sage, Reishi, and Fennel.
It is a product for all women because it is GMO-free, additive-free, dye-free, preservative-free, sweetener-free, sugar-free, soy-free, gluten-free, lactose-free, vegetarian, vegan, comes in openable vegetable capsules (for those who have difficulty swallowing them), and is registered with the Ministry of Health under code n° 166059 and with the certified organic body CCPB IT BIO 009.
It provides a complete intake of phytoestrogens and phytoprogestins that have a protective effect against the risk of developing ovarian and breast cancer and reduce cardiovascular risk. However, it is not recommended for those with a history of cancer.
To be evaluated with your specialist that the red clover contained in the supplement, due to the isoflavones which are part of the phytoestrogen category, is not advisable for women suffering from hormone-sensitive tumors, including fibroids if they are of tumoral origin.
Scientific advice from our research and development department.
Please note that when undergoing pharmacological therapies or suffering from illnesses, it is always advisable to consult your doctor before deciding to add any dietary supplements.
Regarding the safety of our dietary supplement based on phytoestrogens such as isoflavones, in standardized Kudzu and red clover powder, we present a selection of the many publications released over the years, with a brief summary to highlight scientifically proven arguments and address a topic that is always highly debated.
Phytoestrogens are plant-derived compounds that are structurally and functionally similar, although smaller in size, to endogenous estrogens synthesized by the body. More info here!
An analysis of the trend in the incidence of estrogen-dependent tumor pathologies in different parts of the world has shown that the incidence rate of breast cancer is significantly higher in Western countries than in East and Southeast Asia. The reason for this could be found in differences in lifestyle, particularly in diet, which in Eastern countries is rich in soy-based products, which contain high levels of phytoestrogens.
Due to their similarity to endogenous estradiol, but being smaller molecules, phytoestrogens can bind to the same estrogen receptors (ER), exerting milder estrogenic effects, occupying receptor sites and reducing the action of estrogens produced by the body itself. This means that endogenous estrogens, finding the receptor site occupied, cannot exert their proliferative and tumor-promoting action, particularly on breast cells. Therefore, isoflavones, through this limiting control, provide a protective action against breast cancer.
The higher the amount of plant estrogens, the lower the tumor activation by circulating estrogens, which cannot then bind to already occupied receptors.
A further mode of action (described in vitro) is that soy isoflavones increase the synthesis of sex hormone-binding globulin, thus reducing the circulating hormone levels.
This study reports a systematic literature review using the PubMed, Medline, and Web of Science databases with the aim of determining whether it is justified to advise against soy-based products (containing phytoestrogens) in women with a history of breast cancer. 7 studies were included, and the conclusions are:
None of these studies reported statistically significant adverse effects from soy consumption in terms of recurrence or mortality (due to breast cancer or other causes).
Other studies found benefits from soy intake in breast cancer patients, but in variable ways: 2 studies showed a decrease in recurrence associated with higher isoflavone intake only in post-menopausal women; the other 4 studies showed a decrease in recurrence associated with higher isoflavone intake regardless of menopausal status.
Four studies showed better results in women with hormone-sensitive cancer and/or patients undergoing hormonal treatment.
Only one study was unable to detect beneficial effects from soy intake in breast cancer patients.
Regarding Hashimoto's syndrome, it should be specified that isoflavones do not interfere with the thyroid gland. However, supplements containing soy (which our supplement DOES NOT contain) can reduce the absorption of the drug Euthyrox.
The contraindication is therefore not related to isoflavones but specifically to soy.
This is another publication that reports a meta-analysis of observational studies which conclude that dietary isoflavone intake is useful in reducing the risk of breast cancer.
This is a study that evaluates the effects of Pueraria isoflavones on the growth of breast cancer cells. The results showed that Kudzu isoflavones induce a reduction in cell viability and cellular apoptosis. Therefore, it is suggested as a chemopreventive and chemoprotective agent.
This study evaluated the estrogen-like activity of Kudzu isoflavones and their safety with respect to their effect on breast cancer cell proliferation.
– Pausa + Energia contains a daily amount of 64 mg of standardized Kudzu isoflavones. The maximum permitted daily dosage is 80 mg. We deliberately kept it lower because the formula also contains red clover powder, which also contains phytoestrogens.
For any questions, contact us!
